Serotonin (5-hydroxytryptamine, 5-HT) exerts its many physiological effects through 13 distinct receptor subtypes in humans. These subtypes fall into seven structurally-defined classes (5HT1 to 5HT7). 5HT2b receptors are expressed in the brain, vasculature, smooth muscle, uterus, and stomach. This receptor has been used as a target for developing drugs to treat migraine, anxiety, and irritable bowel syndrome.
|Product Description||Frozen membranes from CHO-K1 cells expressing recombinant mouse 5HT2b Serotonin receptors.|
|Therapeutic Area||cardiac, pulmonary-respiratory|
|Related Services||Membrane Preparation, GPCR Screening|
|Genbank Accession Number||Amino acid sequence corresponds exactly to BC023690; no expressed tags.|
|References||Choi, D.-S. et al. (1994) The human serotonin 5-HT2B receptor: pharmacological link between 5-HT2 and 5-HT1D receptors. FEBS Lett. 352: 393-399.
Barnes, N.M. (1999) A review of central 5-HT receptors and their function. Neuropharmacology 38: 1
|Recommended Assay Conditions||Refer to product specification sheet for details|
|Storage and Packaging|
|Packaging||Vials containing 400 µl of membranes at a protein concentration of 2.5 mg/mL|
|Storage Recommendation||Storage at -80oC is recommended.|
|Specification Sheet||Download PDF Document|