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Background
The CB1 cannabinoid receptor is expressed primarily in brain and is a target for cannabinoids (Matsuda et al., 1990, Gerard et al., 1991), the psychoactive ingredients of marijuana. Other members of the cannabinoid family of receptors include the CB2 cannabinoid receptor, which is expressed primarily in the periphery, and GPR55 (Ryberg, 2007). When activated, the CB1 receptor inhibits adenylate cyclase through Gi. The CB1 receptor plays a significant role in modulation of food intake (Cota, 2007).
| General Info | |
| Product Description | Frozen membranes from CHO-K1 cells expressing recombinant rat CB1 Cannabinoid receptors. |
|---|---|
| Target Type | GPCR |
| Product Type | membrane |
| Receptor | Cannabinoid |
| Sub-Type | CB1 |
| Therapeutic Area | metabolic & gastrointestinal, pain & inflammation |
| Related Services | Membrane Preparation, GPCR Screening |
| Genbank Accession Number | NM_012784 |
| References | Matsuda, LA et al., (1990) Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature 346: 561-564. Gerard, C.M et al. (1991) Molecular cloning of a human cannabinoid receptor which is also expressed in testis. Bi |
| Membrane Info | |
| Host cell | CHO-K1 |
| Mycoplasma Status | Negative (MycoAlert Kit) |
| Recommended Assay Conditions | Refer to product specification sheet for details |
| Storage and Packaging | |
| Packaging | 0.4 mL of membrane suspension in storage buffer (20 mM HEPES, pH 7.4, 0.1 mM EDTA, 10% sucrose) at a protein concentration of 4 mg/mL. |
| Storage Recommendation | -80°C; Avoid repeated freeze-thawing of this product. |
| Quantity | 400 µL/vial |
| Media | |
| Specification Sheet |  Download PDF Document |
