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Background
Serotonin (5-hydroxytryptamine, 5-HT) exerts its many physiological effects through 13 distinct receptor subtypes in humans. These subtypes fall into seven structurally-defined classes (5HT1 to 5HT7). 5HT2b receptors are expressed in the brain, vasculature, smooth muscle, uterus, and stomach. This receptor has been used as a target for developing drugs to treat migraine, anxiety, and irritable bowel syndrome.
| General Info | |
| Synonyms | HTR2B |
|---|---|
| Product Description | Frozen membranes from CHO-K1 cells expressing recombinant mouse 5HT2b Serotonin receptors. |
| Target Type | GPCR |
| Product Type | membrane |
| Receptor | Serotonin |
| Sub-Type | 5HT2b |
| Therapeutic Area | cardiac, pulmonary-respiratory |
| Related Services | Membrane Preparation, GPCR Screening |
| Genbank Accession Number | Amino acid sequence corresponds exactly to BC023690; no expressed tags. |
| References | Choi, D.-S. et al. (1994) The human serotonin 5-HT2B receptor: pharmacological link between 5-HT2 and 5-HT1D receptors. FEBS Lett. 352: 393-399. Barnes, N.M. (1999) A review of central 5-HT receptors and their function. Neuropharmacology 38: 1 |
| Membrane Info | |
| Host cell | CHO-K1 |
| Bmax | 4-10 pmol/mg |
| Recommended Assay Conditions | Refer to product specification sheet for details |
| Storage and Packaging | |
| Packaging | Vials containing 400 µl of membranes at a protein concentration of 2.5 mg/mL |
| Storage Recommendation | Storage at -80oC is recommended. |
| Quantity | 400 µL/vial |
| Media | |
| Specification Sheet |  Download PDF Document |
