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Background
Edg receptors constitute of family of 8 GPCRs (designated as Edg-1 through Edg-8) that can be further sub-classified as sphingosine 1-phosphate receptors (S-1-P) and lysophosphatidic acid (LPA) receptors. The Edg-1 receptor is an S-1-P receptor that is coupled to a variety of intracellular responses via Gi and Go. The Edg-1 receptor was initially cloned as an immediate-early gene induced during differentiation of human endothelial cells, an in vitro model of angiogenesis. It has been shown to play a critical role in regulating cellular proliferation and survival.
| General Info | |
| Synonyms | S1P1 |
|---|---|
| Product Description | Frozen membranes from CHO-K1 cells expressing recombinant human Edg1 receptors. |
| Target Type | GPCR |
| Product Type | membrane |
| Receptor | Lysophosphatidic Acid |
| Sub-Type | EDG1 |
| Therapeutic Area | cancer, vascular |
| Related Services | Membrane Preparation, GPCR Screening |
| Genbank Accession Number | NM_001400 |
| Membrane Info | |
| Host cell | CHO-K1 |
| EC50 for Sphingosine-1 Phosphate | 16 nM |
| Recommended Assay Conditions | Refer to product specification sheet for details |
| Storage and Packaging | |
| Packaging | 0.4 mL of membrane suspension in storage buffer (20 mM HEPES pH 7.5, 0.1 mM EDTA, 10% sucrose) at a protein concentration of 2 mg/mL |
| Storage Recommendation | Storage at -80oC is recommended. Repeated freeze- thawing of this product is not recommended. |
| Quantity | 400 µL/vial |
| Protein per vial | 0.8 mg |
| Media | |
| Specification Sheet |  Download PDF Document |
