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Background
Three alpha2-adrenoceptors have been cloned, and are designated alpha2a, alpha2b and alpha2c. All three receptors are activated by norepinephrine and all three are coupled via Gi to adenylate cyclase. The alpha2c adrenergic receptor is widely distributed in the CNS and in lung and mediates vasoconstriction and modulation of neurotransmission.
| General Info | |
| Synonyms | ADRA2C |
|---|---|
| Product Description | Frozen membranes from CHO-K1 cells expressing recombinant human Alpha2c Adrenergic receptors. |
| Target Type | GPCR |
| Product Type | membrane |
| Receptor | Adrenergic |
| Sub-Type | Alpha2c |
| Therapeutic Area | pain & inflammation, psychiatric disorder |
| Related Services | Membrane Preparation, GPCR Screening |
| Genbank Accession Number | NM_000683 |
| Membrane Info | |
| Host cell | CHO-K1 |
| Bmax | 0.75-4 pmol/mg |
| KD | 0.1-1 nM |
| Recommended Assay Conditions | Refer to product specification sheet for details |
| Storage and Packaging | |
| Packaging | 0.4 mL of membrane suspension in storage buffer (10mM Tris, pH 7.5, 0.2 mM EDTA, 10% sucrose) at a protein concentration of 5.0 mg/mL. |
| Storage Recommendation | -80oC; avoid repeated freeze-thawing of this product. |
| Quantity | 400 µL/vial |
| Media | |
| Specification Sheet |  Download PDF Document |
