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Background
Nicotinic receptors constitute a family of ligand-gated ion channels permeable to Na+, K+ and Ca2+. They are composed of various permutations of 10 different alpha subunits and four different beta subunits. The predominant forms of nicotinic receptor in brain are α4β2 and α7. The α3β4 form is a neuronal form that is insensitive to α-bungarotoxin.
| General Info | |
| Synonyms | nACHR |
|---|---|
| Product Description | Human α3/β4 Nicotinic Receptor membrane preparation derived from stable, replicating cell line. |
| Target Type | GPCR |
| Product Type | membrane |
| Receptor | Acetylcholine |
| Sub-Type | a3/β4 |
| Related Services | Membrane Preparation |
| Genbank Accession Number | NM_000743.2 and NM_00750.3 |
| References | Dajas-Bailardor, F. and Wonnacott, S. Nicotinic acetyolcholine receptors and the regulations of neuronal signalling. Trends Pharmacol Sci. 25, 317-324 (2004) |
| Membrane Info | |
| Host cell | CHO-K1 |
| Recommended Assay Conditions | Refer to product specification sheet for details |
| Storage and Packaging | |
| Packaging | 0.4 mL of membrane suspension in storage buffer (10 mM Tris-HCl, pH 7.5, 10% sucrose) at a protein concentration of 1.2 mg/mL. |
| Storage Recommendation | -80°C; Avoid repeated freeze-thawing of this product. |
| Quantity | 400 µL/vial |
| Media | |
| Specification Sheet |  Download PDF Document |
