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Background
Serotonin (5-hydroxytryptamine, 5-HT) exerts its many physiological effects through 13 distinct receptor subtypes in humans. These subtypes fall into seven structurally-defined classes (5HT1 to 5HT7). Among them, 5HT1a receptors are expressed mainly in the CNS system where they induce neuronal inhibition and controls behaviour, such as sleep, food intake, thermoregulation, aggression, and anxiety. This receptor has been used as a target for developing drugs to treat anxiety and depression.
| General Info | |
| Synonyms | HTR1A |
|---|---|
| Product Description | Frozen membranes from CHO-K1 cells expressing recombinant human 5HT1A Serotonin receptors. |
| Target Type | GPCR |
| Product Type | membrane |
| Receptor | Serotonin |
| Sub-Type | 5HT1A |
| Therapeutic Area | neurodegeneration & stroke, psychiatric disorder |
| Related Services | Membrane Preparation, GPCR Screening |
| Genbank Accession Number | NM_000524 |
| Membrane Info | |
| Host cell | CHO-K1 |
| Bmax | 5.1 pmol/mg |
| KD | 343 pM |
| Recommended Assay Conditions | Refer to product specification sheet for details |
| Storage and Packaging | |
| Packaging | Each vial includes 3 aliquots of 400 µl each of membrane suspension in storage buffer (10 mM Tris-HCl pH 7.5, 10% sucrose) at a protein concentration of 1.3 mg/mL. Total protein per vial: 0.52 mg. |
| Storage Recommendation | Storage at -80oC is recommended. Repeated freeze-thawing of this product is not recommended. |
| Quantity | 3 vials; 400 µl/vial |
| Media | |
| Specification Sheet |  Download PDF Document |
