The pituitary hormone vasopressin (AVP) is a cyclic nonapeptide that acts by binding to a family of vasopressin receptors that includes the V1a, V1b, and V2 receptors. V1b receptors are expressed in the anterior pituitary where they mediate ACTH release. Selective V1b antagonists have been shown to have anxiolytic and antidepressant effects. This cell line is useful for both radioligand binding and for functional assays.
|Product Description||Human V1b Vasopressin Receptor-expressing GPCR (G protein-coupled receptor) division-arrested cells.|
|Product Type||EZCells™ DA|
|Therapeutic Area||psychiatric disorder|
|Related Services||Membrane Preparation, GPCR Screening|
|Genbank Accession Number||NM_000707.2|
|Validated Assay/Platform||binding, calcium|
|References||Sugimoto, T., Saito, M. et al., (1994) Molecular Cloning and Functional Expression of a cDNA Encoding the Human V1b Vasopressin Receptor. J. Biol. Chem. 269: 27088-27092.
Van West, D., Del-Favero, J., et al., (2004) A major SNP haplotype of the
|Mycoplasma Status||Negative (MycoAlert Kit)|
|Growth media||Ham's F12, 10% FBS, 1% NEAA, 400 µg/mL G418|
|Storage and Packaging|
|Packaging||Cryopreserved irradiated cells, 6 million cells per vial|
|Storage Recommendation||liquid nitrogen|
|Quantity||6 million cells|
|Specification Sheet||Download PDF Document|