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Background
The pituitary hormone vasopressin (AVP) is a cyclic nonapeptide that acts by binding to a family of vasopressin receptors that includes the V1a, V1b, and V2 receptors. V1b receptors are expressed in the anterior pituitary where they mediate ACTH release. Selective V1b antagonists have been shown to have anxiolytic and antidepressant effects. This cell line is useful for both radioligand binding and for functional assays.
| General Info | |
| Product Description | Human V1b Vasopressin Receptor-expressing GPCR (G protein-coupled receptor) stable, replicating cell line. |
|---|---|
| Target Type | GPCR |
| Product Type | Replicating Cell Line |
| Receptor | Vasopressin |
| Sub-Type | V1b |
| Therapeutic Area | psychiatric disorder |
| Related Services | Membrane Preparation, Large-scale Cryopreservation, GPCR Screening |
| Genbank Accession Number | NM_000707.2; no expressed tags |
| Validated Assay/Platform | binding, calcium |
| References | Sugimoto, T., Saito, M. et al., (1994) Molecular Cloning and Functional Expression of a cDNA Encoding the Human V1b Vasopressin Receptor. J. Biol. Chem. 269: 27088-27092. Van West, D., Del-Favero, J., et al., (2004) A major SNP haplotype of the |
| Host cell | CHO-K1 |
| Bmax | 7 pmol/mg protein |
| Mycoplasma Status | Negative (MycoAlert Kit) |
| Growth media | Ham's F12, 10% FBS, 1% NEAA, 400 µg/mL G418 |
| Storage & Packaging | |
| Packaging | Cryopreserved cells, 6 million cells per vial |
| Storage Recommendation | liquid nitrogen |
| Stability | at least 6 passages |
| Quantity | 6 million cells |
| Product Documentation | |
| Specification Sheet |  Download PDF Document |
