My Cart
You have no items in your shopping cart.
Background
The orexins (orexin-A and orexin-b) have a range of physiological functions including the control of feeding and energy metabolism, modulation of neuroendocrine function, and regulation of the sleep-wake cycle. The two orexin receptor subtypes OX1 and OX2 both mediate the action of orexin-A and orexin-B and couple efficiently through Gq/11 to activate phospholipase C and lead to elevation of intracellular calcium, though orexin-A is equipotent at OX1 and OX2, whilst orexin-B displays a moderate selectivity for OX2.
| General Info | |
| Product Description | Frozen membranes from CHO-K1 cells expressing recombinant human OX2 orexin receptors. |
|---|---|
| Target Type | GPCR |
| Product Type | membrane |
| Receptor | Orexin |
| Sub-Type | OX2 |
| Therapeutic Area | metabolic & gastrointestinal |
| Related Services | Membrane Preparation, GPCR Screening |
| Genbank Accession Number | NM_001526.2 |
| References | Kukkonen JP et al., Functions of the orexinergic/hypocretinergic system. Am. J. Physiol., 283: C1567-C1591 (2002). Lin L et al., The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene. Cell 98: 365- |
| Membrane Info | |
| Host cell | CHO-K1 |
| Bmax | 0.05 pmol/mg |
| KD | 0.41 nM |
| Recommended Assay Conditions | Refer to product specification sheet for details |
| Storage and Packaging | |
| Packaging | 0.4 mL of membranes at a protein concentration of 4 mg/mL. |
| Quantity | 400 µL/vial |
| Media | |
| Specification Sheet |  Download PDF Document |
