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Background
Orexin-A and orexin-B are peptides expressed in brain that have been implicated in controlling feeding behavior, energy homeostasis and sleep-wake cycle. These peptides exert their effects through two GPCRs, known as the orexin-1 and orexin-2 receptors, both of which are Gq/11-coupled.
| General Info | |
| Product Description | Frozen membranes from CHO-K1 cells expressing recombinant human OX1 orexin receptors. |
|---|---|
| Target Type | GPCR |
| Product Type | membrane |
| Receptor | Orexin |
| Sub-Type | OX1 |
| Therapeutic Area | metabolic & gastrointestinal |
| Related Services | Membrane Preparation, GPCR Screening |
| Genbank Accession Number | NM_001525. Protein variation at G280A which is a polymorphism reported by AK290521.1 |
| Membrane Info | |
| Host cell | CHO-K1 |
| Bmax | 0.65 pmol/mg |
| KD | 164 pM |
| Recommended Assay Conditions | Refer to product specification sheet for details |
| Storage and Packaging | |
| Packaging | 0.25 mL of membrane suspension in storage buffer (10 mM Tris-HCl pH 7.5, 10% sucrose) at a protein concentration of 5 mg/mL |
| Storage Recommendation | Storage at -80oC is recommended. Repeated freeze-thawing of this product is not recommended. |
| Quantity | 250 µL/vial |
| Media | |
| Specification Sheet |  Download PDF Document |
