Orexin-A and orexin-B are peptides expressed in brain that have been implicated in controlling feeding behavior, energy homeostasis and sleep-wake cycle. These peptides exert their effects through two GPCRs, known as the orexin-1 and orexin-2 receptors, both of which are Gq/11-coupled.
|Product Description||Human OX1 Orexin Receptor-expressing GPCR (G protein-coupled receptor) division-arrested cells.|
|Product Type||EZCells™ DA|
|Therapeutic Area||metabolic & gastrointestinal|
|Related Services||Membrane Preparation, GPCR Screening|
|Genbank Accession Number||AY062030|
|Validated Assay/Platform||binding, calcium|
|References||akurai, T., et al., Orexins and orexin receptors: A family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior., Cell 92: 573-585 (1998).
Smart, D., et al. Characterization of recombinant human orexin re
|Mycoplasma Status||Negative (MycoAlert Kit)|
|Growth media||Ham's F12, 10% FBS, 1% NEAA, 0.4 mg/mL G418|
|Storage and Packaging|
|Packaging||Cryopreserved irradiated cells, 6 million cells per vial|
|Storage Recommendation||liquid nitrogen|
|Quantity||6 million cells|
|Specification Sheet||Download PDF Document|