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Background
Orexin-A and orexin-B are peptides expressed in brain that have been implicated in controlling feeding behavior, energy homeostasis and sleep-wake cycle. These peptides exert their effects through two GPCRs, known as the orexin-1 and orexin-2 receptors, both of which are Gq/11-coupled.
| General Info | |
| Synonyms | Ox1, Hcrtr1 |
|---|---|
| Product Description | Human OX1 Orexin Receptor-expressing GPCR (G protein-coupled receptor) division-arrested cells. |
| Target Type | GPCR |
| Product Type | EZCells™ DA |
| Receptor | Orexin |
| Sub-Type | OX1 |
| Therapeutic Area | metabolic & gastrointestinal |
| Related Services | Membrane Preparation, GPCR Screening |
| Genbank Accession Number | AY062030 |
| Validated Assay/Platform | binding, calcium |
| References | akurai, T., et al., Orexins and orexin receptors: A family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior., Cell 92: 573-585 (1998). Smart, D., et al. Characterization of recombinant human orexin re |
| EZCell Info | |
| Host cell | CHO-K1 |
| Mycoplasma Status | Negative (MycoAlert Kit) |
| Growth media | Ham's F12, 10% FBS, 1% NEAA, 0.4 mg/mL G418 |
| Storage and Packaging | |
| Packaging | Cryopreserved irradiated cells, 6 million cells per vial |
| Storage Recommendation | liquid nitrogen |
| Quantity | 6 million cells |
| Media | |
| Specification Sheet |  Download PDF Document |
