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Background
The five muscarinic receptor subtypes all mediate the action of acetylcholine. The odd-numbered receptors (m1, m3, and m5) couple efficiently through Gq/11 to activate phospholipase C and lead to elevation of intracellular calcium, whereas the even-numbered receptors (m2, M4) are efficiently coupled to Gi and lead to inhibition of intracellular cAMP along with several other signal transduction pathways.
| General Info | |
| Product Description | Frozen membranes from CHO-K1 cells expressing recombinant human M5 muscarinic receptors. |
|---|---|
| Target Type | GPCR |
| Product Type | membrane |
| Receptor | Muscarinic |
| Sub-Type | m5 |
| Related Services | Membrane Preparation, GPCR Screening |
| Genbank Accession Number | M80333 |
| Membrane Info | |
| Host cell | CHO-K1 |
| Bmax | 2.7 pmol/mg |
| KD | 516 pM |
| Recommended Assay Conditions | Refer to product specification sheet for details |
| Storage and Packaging | |
| Packaging | 0.4 mL of membrane suspension in storage buffer (10 mM Tris-HCl pH 7.8, 10% sucrose) at a protein concentration of 7.5 mg/mL |
| Storage Recommendation | Storage at -80oC is recommended. Repeated freeze-thawing of this product is not recommended. |
| Quantity | 400 µL/vial |
| Media | |
| Specification Sheet |  Download PDF Document |
