GPR103 is a G-protein coupled receptor that has been shown to be expressed primarily in brain, heart, kidney, adrenal gland, retina and testis. Its ligand has been identified as a 43-residue RF-amide peptide known as QRFP. When administered centrally in mice, QRFP was shown to increase feeding, behavioral arousal and blood pressure. When administered iv, this peptide caused release of aldosterone. Knockout mice (GPR103 -/-) have suggested a role of GPR103 in regulating bone formation. These diverse but important physiological functions of this receptor and ligand make them important possible targets for drug discovery in several fields.
|Product Description||Human GPR103 Receptor-expressing GPCR (G protein-coupled receptor) division-arrested cells.|
|Product Type||EZCells™ DA|
|Therapeutic Area||metabolic & gastrointestinal|
|Related Services||Membrane Preparation, GPCR Screening|
|Genbank Accession Number||AF411117|
|References||Jiang, Y., Luo, L., et al., (2003) Identification and Charcterization of a Novel RF-amide Peptide Ligand for Orphan G-protein-coupled Receptor SP9155. J. Biol. Chem. 278: 27652-27657.
Takayasu, S., Sakurai, T., et al., (2006) A neuropeptide ligand
|Mycoplasma Status||Negative (MycoAlert Kit)|
|Growth media||Ham's F12, 10% FBS, 1% NEAA, 400 µg/mL G418|
|Storage and Packaging|
|Packaging||Cryopreserved irradiated cells, 6 million cells per vial|
|Storage Recommendation||liquid nitrogen|
|Quantity||6 million cells|
|Specification Sheet||Download PDF Document|