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Background
The FPR1, FPRL1 and FPRL2 receptors belongs to a family of receptors that all respond to N-formyl peptides. N-Formyl peptides are bacterial peptides which induce chemotaxis in neutrophils and other phagocytic cells to sites of bacterial infection. This cell line allows FPR1 to couple to the intracellular signaling pathway through Ga16, and should be useful for screening compounds for activity as modulators of host defense mechanisms against bacterial infection and in the regulation of inflammatory responses.
| General Info | |
| Product Description | Human FPRL1 Receptor-expressing GPCR (G protein-coupled receptor) stable, replicating cell line. |
|---|---|
| Target Type | GPCR |
| Product Type | Replicating Cell Line |
| Receptor | Formylpeptide |
| Sub-Type | FPRL1 |
| Therapeutic Area | cancer, neurodegeneration & stroke |
| Related Services | Membrane Preparation, Large-scale Cryopreservation, GPCR Screening |
| Genbank Accession Number | NM_002029.3 and Ga16 |
| Validated Assay/Platform | calcium |
| References | Murphy, P.M., Ozcelik, T., et al., (1992) A Structural Homologue of the N-Formyl Peptide Receptor. J. Biol. Chem. 267: 7637-7643. Klotz, K.N. and Jesaitis, A.J. (1994) Physical coupling of N-formyl peptide chemoattractant receptors to G protein |
| Host cell | CHO-K1 |
| Mycoplasma Status | Negative (MycoAlert Kit) |
| Growth media | Ham's F12, 10% FBS, 1% NEAA, 400 µg/mL G418 |
| Storage & Packaging | |
| Packaging | Cryopreserved cells, 6 million cells per vial |
| Storage Recommendation | liquid nitrogen |
| Stability | At least 6 passages |
| Quantity | 6 million cells |
| Product Documentation | |
| Specification Sheet |  Download PDF Document |
