The CB2 cannabinoid receptor is expressed primarily in cells of the peripheral immune system and is a target for cannabinoids (Munro et al., 1993; Gerard et al., 1991), the psychoactive ingredients of marijuana. Other members of the cannabinoid family of receptors include the CB1 cannabinoid receptor, which is expressed primarily in brain, and GPR55 (Ryberg, 2007). When activated, the CB2 receptor inhibits adenylate cyclase by coupling through Gi.
|Product Description||Human CB2 Cannabinoid Receptor-expressing GPCR (G protein-coupled receptor) stable, replicating cell line.|
|Product Type||Replicating Cell Line|
|Therapeutic Area||neurodegeneration & stroke, pain & inflammation|
|Related Services||Membrane Preparation, Large-scale Cryopreservation, GPCR Screening|
|Genbank Accession Number||AY242132|
|Validated Assay/Platform||binding, cAMP|
|References||Munro,S., et al., (1993) Molecular characterization of a peripheral receptor for Cannabinoids Nature 365:6441), 61-65 (1993)
Gerard, C.M et al. (1991) Molecular cloning of a human cannabinoid receptor which is also expressed in testis. Biochem. J.
|Mycoplasma Status||Negative (MycoAlert Kit)|
|Growth media||Ham's F12, 10% FBS, 1% NEAA, 400 µg/mL G418|
|Storage & Packaging|
|Packaging||Cryopreserved cells, 6 million cells per vial|
|Storage Recommendation||liquid nitrogen|
|Quantity||6 million cells|
|Specification Sheet||Download PDF Document|