Three alpha2-adrenoceptors have been cloned, and are designated alpha2a, alpha2b and alpha2c. All three receptors are activated by norepinephrine and all three are coupled via Gi to adenylate cyclase. The alpha2a adrenergic receptor is widely distributed in the CNS, lung, blood vessels and skeletal muscle and mediates vasoconstriction and inhibition of neurotransmission.
|Product Description||Frozen membranes from CHO-K1 cells expressing recombinant human Alpha2a Adrenergic receptors.|
|Therapeutic Area||cardiac, metabolic & gastrointestinal, pain & inflammation, seizure-convulsion, vascular|
|Related Services||Membrane Preparation, GPCR Screening|
|Genbank Accession Number||Amino acid sequence corresponds exactly to NM_000681; no expressed tags.|
|References||Hieble, J.P., et al, (1995) Alpha and beta-adrenoceptors: From the gene to the clinic. Part I. J. Med. Chem. 38: 3415-3444.
Wang, C.D. et al (1991) Site-directed mutagenesis of alpha 2A-adrenergic receptors: identification of amino acids inv
|Bmax||10-19 pmol/mg protein|
|Recommended Assay Conditions||Refer to product specification sheet for details|
|Storage and Packaging|
|Packaging||Vials containing 400 µl of membranes at a protein concentration of 2.5 mg/mL.|
|Storage Recommendation||Storage at -80oC is recommended. Repeated freeze-thawing of this product is not recommended.|
|Specification Sheet||Download PDF Document|