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Background
Three alpha2-adrenoceptors have been cloned, and are designated alpha2a, alpha2b and alpha2c. All three receptors are activated by norepinephrine and all three are coupled via Gi to adenylate cyclase. The alpha2a adrenergic receptor is widely distributed in the CNS, lung, blood vessels and skeletal muscle and mediates vasoconstriction and inhibition of neurotransmission.
| General Info | |
| Synonyms | ADRA2A |
|---|---|
| Product Description | Human Alpha2a Adrenergic Receptor-expressing GPCR (G protein-coupled receptor) stable, replicating cell line. |
| Target Type | GPCR |
| Product Type | Replicating Cell Line |
| Receptor | Adrenergic |
| Sub-Type | Alpha2a |
| Therapeutic Area | cardiac, metabolic & gastrointestinal, pain & inflammation, seizure-convulsion, vascular |
| Related Services | Membrane Preparation, Large-scale Cryopreservation, GPCR Screening |
| Genbank Accession Number | Amino acid sequence corresponds exactly to NM_000681; no expressed tags. |
| Validated Assay/Platform | binding, cAMP |
| References | Hieble, J.P., et al, (1995) Alpha and beta-adrenoceptors: From the gene to the clinic. Part I. J. Med. Chem. 38: 3415-3444. Wang, C.D. et al (1991) Site-directed mutagenesis of alpha 2A-adrenergic receptors: identification of amino acids inv |
| Host cell | CHO-K1 |
| Bmax | 19 pmol/mg protein |
| Mycoplasma Status | Negative (MycoAlert Kit) |
| Growth media | Ham's F12, 10% dialyzed FBS, 0.4 mg/mL G418 |
| Storage & Packaging | |
| Packaging | Cryopreserved cells, 6 million cells per vial |
| Storage Recommendation | liquid nitrogen |
| Stability | 12 passages (6 weeks of continuous culture) |
| Quantity | 6 million cells |
| Product Documentation | |
| Specification Sheet |  Download PDF Document |
