Serotonin (5-hydroxytryptamine, 5-HT) exerts its many physiological effects through 13 distinct receptor subtypes in humans. These subtypes fall into seven structurally-defined classes (5HT1 to 5HT7). 5HT2c receptors are expressed in brain and choroid plexus. This receptor has been used as a target for developing drugs to treat migraine and obesity.
|Product Description||Human 5HT2c Serotonin Receptor-expressing GPCR (G protein-coupled receptor) stable, replicating cell line.|
|Product Type||Replicating Cell Line|
|Therapeutic Area||metabolic & gastrointestinal, neurodegeneration & stroke, psychiatric disorder|
|Related Services||Membrane Preparation, Large-scale Cryopreservation, GPCR Screening|
|Genbank Accession Number||Amino acid sequence corresponds exactly to NM_000868; no expressed tags.|
|References||Choi, D.-S. et al. (1994) The human serotonin 5-HT2B receptor: pharmacological link between 5-HT2 and 5-HT1D receptors. FEBS Lett. 352: 393-399.
Barnes, N.M. (1999) A review of central 5-HT receptors and their function. Neuropharmacology 38: 1
|Mycoplasma Status||Negative (MycoAlert Kit)|
|Growth media||Ham's F12, 10% dFBS, 0.4 mg/mL G418|
|Storage & Packaging|
|Packaging||Cryopreserved cells, 6 million cells per vial|
|Storage Recommendation||liquid nitrogen|
|Stability||12 passages (6 weeks of continuous culture)|
|Quantity||6 million cells|
|Specification Sheet||Download PDF Document|