My Cart
You have no items in your shopping cart.
Background
Serotonin (5-hydroxytryptamine, 5-HT) exerts its many physiological effects through 13 distinct receptor subtypes in humans. These subtypes fall into seven structurally-defined classes (5HT1 to 5HT7). 5HT2c receptors are expressed in brain and choroid plexus. This receptor has been used as a target for developing drugs to treat migraine and obesity.
| General Info | |
| Synonyms | HTR2C |
|---|---|
| Product Description | Human 5HT2c Serotonin Receptor-expressing GPCR (G protein-coupled receptor) stable, replicating cell line. |
| Target Type | GPCR |
| Product Type | Replicating Cell Line |
| Receptor | Serotonin |
| Sub-Type | 5HT2c |
| Therapeutic Area | metabolic & gastrointestinal, neurodegeneration & stroke, psychiatric disorder |
| Related Services | Membrane Preparation, Large-scale Cryopreservation, GPCR Screening |
| Genbank Accession Number | Amino acid sequence corresponds exactly to NM_000868; no expressed tags. |
| Validated Assay/Platform | binding |
| References | Choi, D.-S. et al. (1994) The human serotonin 5-HT2B receptor: pharmacological link between 5-HT2 and 5-HT1D receptors. FEBS Lett. 352: 393-399. Barnes, N.M. (1999) A review of central 5-HT receptors and their function. Neuropharmacology 38: 1 |
| Host cell | CHO-K1 |
| Mycoplasma Status | Negative (MycoAlert Kit) |
| Growth media | Ham's F12, 10% dFBS, 0.4 mg/mL G418 |
| Storage & Packaging | |
| Packaging | Cryopreserved cells, 6 million cells per vial |
| Storage Recommendation | liquid nitrogen |
| Stability | 12 passages (6 weeks of continuous culture) |
| Quantity | 6 million cells |
| Product Documentation | |
| Specification Sheet |  Download PDF Document |
