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Background
The CB1 cannabinoid receptor is expressed primarily in brain and is a target for cannabinoids (Matsuda et al., 1990, Gerard et al., 1991), the psychoactive ingredients of marijuana. Other members of the cannabinoid family of receptors include the CB2 cannabinoid receptor, which is expressed primarily in the periphery, and GPR55 (Ryberg, 2007). When activated, the CB1 receptor inhibits adenylate cyclase through Gi. The CB1 receptor plays a significant role in modulation of food intake (Cota, 2007).
| General Info | |
| Product Description | Rat CB1 Cannabinoid Receptor-expressing GPCR (G protein-coupled receptor) stable, replicating cell line. |
|---|---|
| Target Type | GPCR |
| Product Type | Replicating Cell Line |
| Receptor | Cannabinoid |
| Sub-Type | CB1 |
| Therapeutic Area | metabolic & gastrointestinal, pain & inflammation |
| Related Services | Membrane Preparation, Large-scale Cryopreservation, GPCR Screening |
| Genbank Accession Number | NM_012784 |
| Validated Assay/Platform | binding, cAMP |
| References | Matsuda, LA et al., (1990) Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature 346: 561-564. Gerard, C.M et al. (1991) Molecular cloning of a human cannabinoid receptor which is also expressed in testis. Bi |
| Host cell | CHO-K1 |
| Mycoplasma Status | Negative (MycoAlert Kit) |
| Growth media | Ham's F12, 10% FBS, 1% NEAA, 400 µg/mL G418 |
| Storage & Packaging | |
| Packaging | Cryopreserved cells, 6 million cells per vial |
| Storage Recommendation | liquid nitrogen |
| Quantity | 6 million cells |
| Product Documentation | |
| Specification Sheet |  Download PDF Document |
