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Background
Three alpha2-adrenoceptors have been cloned, and are designated alpha2a, alpha2b and alpha2c. All three receptors are activated by norepinephrine and all three are coupled via Gi to adenylate cyclase. The alpha2c adrenergic receptor is widely distributed in the CNS and in lung and mediates vasoconstriction and modulation of neurotransmission.
| General Info | |
| Synonyms | ADRA2C |
|---|---|
| Product Description | Human Alpha2c Adrenergic Receptor-expressing GPCR (G protein-coupled receptor) stable, replicating cell line. |
| Target Type | GPCR |
| Product Type | Replicating Cell Line |
| Receptor | Adrenergic |
| Sub-Type | Alpha2c |
| Therapeutic Area | pain & inflammation, psychiatric disorder |
| Related Services | Membrane Preparation, Large-scale Cryopreservation, GPCR Screening |
| Genbank Accession Number | Amino acid sequence corresponds exactly to NM_000683; no expressed tags. |
| Validated Assay/Platform | binding, cAMP |
| References | Hieble, J.P., et al, (1995) Alpha and beta-adrenoceptors: From the gene to the clinic. Part I. J. Med. Chem. 38: 3415-3444. Regan, J.W. et al (1988) Cloning and expression of a human kidney cDNA for an alpha2-adrenergic receptor subtype. Pro |
| Host cell | CHO-K1 |
| Bmax | 3 pmol/mg protein |
| Mycoplasma Status | Negative (MycoAlert Kit) |
| Growth media | Ham's F12, 10% dialyzed FBS, 0.4 mg/mL G418 |
| Storage & Packaging | |
| Packaging | Cryopreserved cells, 6 million cells per vial |
| Storage Recommendation | liquid nitrogen |
| Stability | 12 passages (6 weeks of continuous culture) |
| Quantity | 6 million cells |
| Product Documentation | |
| Specification Sheet |  Download PDF Document |
