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Background
Adenosine is a neuromodulator that is widely distributed in the central and peripheral nervous systems. Many of the actions of adenosine are mediated through G protein-coupled adenosine receptors. Adenosine receptors have been classified into A1, A2A, A2B, and A3 subtypes. Modulation of adenosine receptors by selective agonists and antagonists has potential for the treatment of various cardiovascular inflammatory and neurological diseases.
| General Info | |
| Synonyms | ADORA1 |
|---|---|
| Product Description | Human Adenosine A1 Receptor-expressing GPCR (G protein-coupled receptor) stable, replicating cell line. |
| Target Type | GPCR |
| Product Type | Replicating Cell Line |
| Receptor | Adenosine |
| Sub-Type | A1 |
| Therapeutic Area | cardiac, metabolic & gastrointestinal, pain & inflammation, pulmonary-respiratory |
| Related Services | Membrane Preparation, Large-scale Cryopreservation, GPCR Screening |
| Genbank Accession Number | NM_000674 |
| Validated Assay/Platform | cAMP |
| References | Mahan, LC., et al. (1991) Cloning and expression of an A1 adenosine receptor from rat brain. Molecular Pharmacology 40:1-7 Musser, B., et al. (1999) Adenosine A1 Receptor-Dependent and –Independent Effects of the Allosteric Enhancer PD81,723. Th |
| Host cell | CHO-K1 |
| Mycoplasma Status | Negative (MycoAlert Kit) |
| Growth media | Ham's F12, 10% dFBS, 1% NEAA, 400 µg/mL G418 |
| Storage & Packaging | |
| Packaging | Cryopreserved cells, 6 million cells per vial |
| Storage Recommendation | liquid nitrogen |
| Stability | 12 passages (6 weeks of continuous culture) |
| Quantity | 6 million cells |
| Product Documentation | |
| Specification Sheet |  Download PDF Document |
