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Background
Serotonin (5-hydroxytryptamine, 5-HT) exerts its many physiological effects through 13 distinct receptor subtypes in humans. These subtypes fall into seven structurally-defined classes (5HT1 to 5HT7). 5HT2b receptors are expressed in the brain, vasculature, smooth muscle, uterus, and stomach. This receptor has been used as a target for developing drugs to treat migraine, anxiety, and irritable bowel syndrome.
| General Info | |
| Synonyms | HTR2B |
|---|---|
| Product Description | Mouse 5HT2B Serotonin Receptor-expressing GPCR (G protein-coupled receptor) division-arrested cells. |
| Target Type | GPCR |
| Product Type | EZCells™ DA |
| Receptor | Serotonin |
| Sub-Type | 5HT2B |
| Therapeutic Area | cardiac, pulmonary-respiratory |
| Related Services | Membrane Preparation, GPCR Screening |
| Genbank Accession Number | Amino acid sequence corresponds exactly to BC023690; no expressed tags. |
| Validated Assay/Platform | binding, cAMP |
| References | Choi, D.-S. et al. (1994) The human serotonin 5-HT2B receptor: pharmacological link between 5-HT2 and 5-HT1D receptors. FEBS Lett. 352: 393-399. Barnes, N.M. (1999) A review of central 5-HT receptors and their function. Neuropharmacology 38: 1 |
| EZCell Info | |
| Host cell | CHO-K1 |
| Mycoplasma Status | Negative (MycoAlert Kit) |
| Growth media | Ham's F12, 10% dialyzed FBS, 1% NEAA, 400 µg/mL G418 |
| Storage and Packaging | |
| Packaging | Cryopreserved irradiated cells, 6 million cells per vial |
| Storage Recommendation | liquid nitrogen |
| Quantity | 6 million cells |
| Media | |
| Specification Sheet |  Download PDF Document |
