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Background
Prokineticins are small proteins expressed in the GI tract and other tissues that regulate contraction of GI smooth muscle, angiogenesis and other responses. Two closely related receptors for prokineticins have been cloned, PKR1 and PKR2. PKR2 is expressed in ileocecum, in brain and in endocrine tissues. PKR2 is Gq coupled and has been shown to be activated by mamba intestinal toxin (MIT1). This PKR2-expressing cell line displays a very robust calcium response and is useful as a target for drug discovery.
| General Info | |
| Synonyms | GPR73L1, prokineticin |
|---|---|
| Product Description | Human PKR2 Prokineticin-expressing GPCR (G protein-coupled receptor) stable, replicating cell line. |
| Target Type | GPCR |
| Product Type | Replicating Cell Line |
| Receptor | Prokineticin |
| Sub-Type | PKR2 |
| Therapeutic Area | pain & inflammation |
| Related Services | Membrane Preparation, Large-scale Cryopreservation, GPCR Screening |
| Genbank Accession Number | NM_144773 |
| Validated Assay/Platform | calcium |
| References | Lin, D.CH., Bullock, C.M., et al., (2002) Identification and Molecular Characterization of Two Closely Related G Protein-coupled Receptors Activated by Prokineticins/Endocrine Gland Vascular Endothelial Growth Factor. J. Biol. Chem. 277: 19276-19280. |
| Host cell | CHO-K1 |
| Mycoplasma Status | Negative (MycoAlert Kit) |
| Growth media | Ham's F12, 10% FBS, 1% NEAA, 400 µg/mL G418 |
| Storage & Packaging | |
| Packaging | Cryopreserved cells, 6 million cells per vial |
| Storage Recommendation | liquid nitrogen |
| Stability | at least 8 passages |
| Quantity | 6 million cells |
| Product Documentation | |
| Specification Sheet |  Download PDF Document |
