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Background
The human P2Y family of metabotropic receptors include eight accepted members, including P2Y1,2,4,6,11,12,13,14. P2Y2,4,11 are activated mainly by nucleoside triphosphates whereas P2Y1,6,12,13 are activated by nucleoside diphosphates. P2Y6 couples preferentially to Gq/11 and is expressed in a variety of tissues including endothelia, smooth muscle, heart, gall-bladder, retina, placenta, spleen.
| General Info | |
| Synonyms | P2RY6 |
|---|---|
| Product Description | Human P2Y6 Purinergic Receptor-expressing GPCR (G protein-coupled receptor) stable, replicating cell line. |
| Target Type | GPCR |
| Product Type | Replicating Cell Line |
| Receptor | Purinergic |
| Sub-Type | P2Y6 |
| Therapeutic Area | pain & inflammation, vascular |
| Related Services | Membrane Preparation, Large-scale Cryopreservation, GPCR Screening |
| Genbank Accession Number | NM_176797 |
| Validated Assay/Platform | calcium |
| References | Jacobson, K.A., et al., (2004) Molecular recognition at purine and pyrimidine nucleotide (P2) receptors. Curr. Top. Med. Chem. 4: 805-819. Burnstock, G., et al., (2004) Cellular distribution and functions of P2 receptor subtypes in different syst |
| Host cell | 1321N1 astrocytoma |
| Mycoplasma Status | Negative (MycoAlert Kit) |
| Growth media | DMEM, 10% FBS, 1x NEAA, 0.4 mg/mL G418 |
| Storage & Packaging | |
| Packaging | Cryopreserved cells, 6 million cells per vial |
| Storage Recommendation | liquid nitrogen |
| Stability | 12 passages (6 weeks of continuous culture) |
| Quantity | 6 million cells |
| Product Documentation | |
| Specification Sheet |  Download PDF Document |
