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Background
This receptor belongs to a group of 4 sensory neuron-specific G-protein coupled receptors that are expressed solely in small diameter primary sensory neurons. MRGX1 (MAS-related GPR-X1), also known as SNSR4 (sensory neuron-specific G-protein-coupled receptor 4), is potently activated by BAM22 which evokes a large rise in intracellular calcium (see below). Because of their very selective expression pattern in sensory neurons and because these sensory neurons transmit pain, these receptors are of interest as therapeutic targets for the development of pain medications.
| General Info | |
| Synonyms | hSNSR4, Hs. mrgX1 |
|---|---|
| Product Description | Human Mrg-X1 Receptor-expressing GPCR (G protein-coupled receptor) division-arrested cells. |
| Target Type | GPCR |
| Product Type | EZCells™ DA |
| Receptor | Mas-related |
| Sub-Type | Mrg-X1 |
| Therapeutic Area | pain & inflammation |
| Related Services | Membrane Preparation, GPCR Screening |
| Genbank Accession Number | AY042213 |
| Validated Assay/Platform | calcium |
| References | Chen, H., and Ikeda, S.R. (2004) Modulation of Ion Channels and Synaptic Transmission by a Human Sensory Neuron-Specific G-Protein-Coupled Receptor, SNSR4/mrgX1, Heterologously Expressed in Cultured Rat Neurons. J. of Neuroscience 24: 5044-5053. |
| EZCell Info | |
| Host cell | CHO-K1 |
| Mycoplasma Status | Negative (MycoAlert Kit) |
| Growth media | Ham's F12, 10% FBS, 1% NEAA, 400 µg/mL G418 |
| Storage and Packaging | |
| Packaging | Cryopreserved irradiated cells, 6 million cells per vial |
| Storage Recommendation | liquid nitrogen |
| Quantity | 6 million cells |
| Media | |
| Specification Sheet |  Download PDF Document |
