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Background
This receptor belongs to a group of 4 sensory neuron-specific G-protein coupled receptors that are expressed solely in small diameter primary sensory neurons. MRGX1 (MAS-related GPR-X1), also known as SNSR4 (sensory neuron-specific G-protein-coupled receptor 4), is potently activated by BAM22 which evokes a large rise in intracellular calcium. Because of their very selective expression pattern in sensory neurons and because these sensory neurons transmit pain, these receptors are of interest as therapeutic targets for the development of pain medications.
| General Info | |
| Synonyms | hSNSR4, Hs. mrgX1 |
|---|---|
| Product Description | Human MrgX1 Receptor-expressing GPCR (G protein-coupled receptor) stable, replicating cell line. |
| Target Type | GPCR |
| Product Type | Replicating Cell Line |
| Receptor | Mas-related |
| Sub-Type | Mrg-X1 |
| Therapeutic Area | pain & inflammation |
| Related Services | Membrane Preparation, Large-scale Cryopreservation, GPCR Screening |
| Genbank Accession Number | AY042213 |
| Validated Assay/Platform | calcium |
| References | Chen, H., and Ikeda, S.R. (2004) Modulation of Ion Channels and Synaptic Transmission by a Human Sensory Neuron-Specific G-Protein-Coupled Receptor, SNSR4/mrgX1, Heterologously Expressed in Cultured Rat Neurons. J. of Neuroscience 24: 5044-5053. |
| Host cell | CHO-K1 |
| Mycoplasma Status | Negative (MycoAlert Kit) |
| Growth media | Ham's F12, 10% FBS, 1% NEAA, 400 µg/mL G418 |
| Storage & Packaging | |
| Packaging | Cryopreserved cells, 6 million cells per vial |
| Storage Recommendation | liquid nitrogen |
| Stability | At least 6 passages |
| Quantity | 6 million cells |
| Product Documentation | |
| Specification Sheet |  Download PDF Document |
