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Background
LPA4 (GPR23) is lysophosphatidic acid receptor that is distantly related to the Edg family of receptors. It is expressed in significant abundance in ovary. When stimulated with LPA, this cell line showed a robust increase in intracellular calcium mobilization, whereas wild-type HEK293 cells show only a small response at very high concentrations of LPA.
| General Info | |
| Synonyms | GPR23, p2y9 |
|---|---|
| Product Description | Human LPA4 Lysophospholipid-expressing GPCR (G protein-coupled receptor) stable, replicating cell line. |
| Target Type | GPCR |
| Product Type | Replicating Cell Line |
| Receptor | Lysophospholipid |
| Sub-Type | LPA4 |
| Related Services | Membrane Preparation, Large-scale Cryopreservation, GPCR Screening |
| Genbank Accession Number | NM_005296 |
| Validated Assay/Platform | calcium |
| References | Noguchi, K., Ishii, S., et al., (2003) Identification of p2y9/GPR23 as a Novel G Protein-coupled Receptor for Lysophosphatidic Acid, Structurally Distant from the Edg Family. J. Biol. Chem. 278: 25600-25606. |
| Host cell | HEK293 |
| Mycoplasma Status | Negative (MycoAlert Kit) |
| Growth media | DMEM, 10% FBS, 1% NEAA, 400 µg/mL G418 |
| Storage & Packaging | |
| Packaging | Cryopreserved cells, 6 million cells per vial |
| Storage Recommendation | liquid nitrogen |
| Stability | at least 8 passages |
| Quantity | 6 million cells |
| Product Documentation | |
| Specification Sheet |  Download PDF Document |
