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Background
Thromboxane A2 are prostanoids that cause contraction of vascular smooth muscle and aggregation of platelets. Two splice variants of the receptor for thromboxane A2 have been identified, that differ in their C-termini. Our cell line expresses the beta splice variant found expressed primarily in endothelium.
| General Info | |
| Synonyms | TP receptor |
|---|---|
| Product Description | Human Thromboxane A2-expressing GPCR (G protein-coupled receptor) stable, replicating cell line. |
| Target Type | GPCR |
| Product Type | Replicating Cell Line |
| Receptor | Thromboxane |
| Sub-Type | A2 |
| Related Services | Membrane Preparation, Large-scale Cryopreservation, GPCR Screening |
| Genbank Accession Number | NM_001060 |
| Validated Assay/Platform | binding |
| References | Hirata, M., Hayashi, Y., et al., (1991) Cloning and expression of cDNA for a human thromboxane A2 receptor. Nature 349: 617-620. Nusing, R.M., Hirata, M., et al (1993) Characterization and chromosomal mapping of the human thromboxane A2 receptor g |
| Host cell | HEK293 |
| Bmax | 21 pmol/mg protein |
| Mycoplasma Status | Negative (MycoAlert Kit) |
| Growth media | Ham's F12, 10% FBS, 1% NEAA, 5 µg/mL plasmocin, 400 µg/mL G418 |
| Storage & Packaging | |
| Packaging | Cryopreserved cells, 6 million cells per vial |
| Storage Recommendation | liquid nitrogen |
| Stability | at least 6 passages |
| Quantity | 6 million cells |
| Product Documentation | |
| Specification Sheet |  Download PDF Document |