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Background
Adenosine is a neuromodulator that is widely distributed in the central and peripheral nervous systems. Many of the actions of adenosine are mediated through G protein-coupled adenosine receptors. Adenosine receptors have been classified into A1, A2A, A2B, and A3 subtypes. Modulation of adenosine receptors by selective agonists and antagonists has potential for the treatment of various cardiovascular inflammatory and neurological diseases.
| General Info | |
| Synonyms | ADORA1 |
|---|---|
| Product Description | Human A1 Adenosine Receptor-expressing GPCR (G protein-coupled receptor) division-arrested cells. Adenosine is a neuromodulator that is widely distributed in the central and peripheral nervous systems. Modulation of adenosine receptors by selective agonists and antagonists has potential for the treatment of various cardiovascular inflammatory and neurological diseases. |
| Target Type | GPCR |
| Product Type | EZCells™ DA |
| Receptor | Adenosine |
| Sub-Type | A1 |
| Therapeutic Area | cardiac, metabolic & gastrointestinal, pain & inflammation, pulmonary-respiratory |
| Related Services | Membrane Preparation, GPCR Screening |
| Genbank Accession Number | NM_000674 |
| Validated Assay/Platform | cAMP |
| References | Mahan, LC., et al. (1991) Cloning and expression of an A1 adenosine receptor from rat brain. Molecular Pharmacology 40:1-7 Musser, B., et al. (1999) Adenosine A1 Receptor-Dependent and –Independent Effects of the Allosteric Enhancer PD81,723. Th |
| EZCell Info | |
| Host cell | CHO-K1 |
| Mycoplasma Status | Negative (MycoAlert Kit) |
| Growth media | Ham's F12, 10% dFBS, 1% NEAA, 400µg/mL G418 |
| Storage and Packaging | |
| Packaging | Cryopreserved irradiated cells, 6 million cells per vial |
| Storage Recommendation | liquid nitrogen |
| Quantity | 6 million cells |
| Media | |
| Specification Sheet |  Download PDF Document |