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Background
Gastric inhibitory polypeptide (GIP) is a 42-amino acid polypeptide synthesized by K-cells of the duodenum and small intestine. GIP’s principle physiological action is to stimulate insulin secretion from pancreatic β-cells in a glucose-dependent manner. Additional effects of GIP have been described, including effects on lipid metabolism, stimulation of glucagons and somatostatin release. GIP exerts its effects by binding to its specific receptor, the GIP receptor which belongs to the VIP/glucagon/secretin family of G protein-coupled receptors and is positively coupled to adenylyl cyclase but not to phospholipase C.
| General Info | |
| Synonyms | glucose-dependent insulinotropic peptide receptor |
|---|---|
| Product Description | Human GIPR Gastric Inhibitory Polypeptide Receptor-expressing GPCR (G protein-coupled receptor) division-arrested cells. Gastric inhibitory polypeptide (GIP) is a 42-amino acid polypeptide synthesized by K-cells of the duodenum and small intestine. GIP’s principle physiological action is to stimulate insulin secretion from pancreatic β-cells in a glucose-dependent manner. Additional effects of GIP have been described, including effects on lipid metabolism, stimulation of glucagons and somatostatin release. GIP exerts its effects by binding to its specific receptor, the GIP receptor which belongs to the VIP/glucagon/secretin family of G protein-coupled receptors and is positively coupled to adenylyl cyclase but not to phospholipase C. |
| Target Type | GPCR |
| Product Type | EZCells™ DA |
| Receptor | Gastric Inhibitory Polypeptide |
| Sub-Type | GIPR |
| Therapeutic Area | metabolic & gastrointestinal |
| Related Services | Membrane Preparation, GPCR Screening |
| Genbank Accession Number | NM_000164 |
| Validated Assay/Platform | binding, cAMP |
| References | Usdin, T., et al (1993) Gastric Inhibitory Polypeptide Receptor, a Member of the Secretin-Vasoactive Instestinal Peptide Receptor Family, Is Widely Distributed in Peripheral Organs and the Brain. Endocrinology 133(6): 2861-70. |
| EZCell Info | |
| Host cell | CHO-K1 |
| Mycoplasma Status | Negative (MycoAlert Kit) |
| Growth media | Ham's F12, 10% FBS, 1% NEAA, 500 µg/mL G418 |
| Storage and Packaging | |
| Packaging | Cryopreserved irradiated cells, 6 million cells per vial |
| Storage Recommendation | liquid nitrogen |
| Quantity | 6 million cells |
| Media | |
| Specification Sheet |  Download PDF Document |
