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Human CCKA Cholecystokinin Receptor EZCells™

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  • Calcium dose-response forCCK-8 stimulation of CCKA EZCells™ compared to non-irradiated cells. CHO-K1 cells that stably express the CCKA receptor (black Squares) and similar cells that were irradiated (green triangles) were loaded with Fluo-4 NW, and then stimulated with the indicated concentrations of CCK-8. The resulting increase in intracellular calcium was measured on a FlexStation fluorescent plate reader. Data points represent the average +/- standard deviation of triplicate determinations.

Human CCKA Cholecystokinin Receptor EZCells™

  • Cat.#:
  • A488
  • Lot #:
  • 938

Availability: In stock

Price: $275.00
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Quick Overview

Human CCKA Cholecystokinin Receptor-expressing GPCR (G protein-coupled receptor) division-arrested cells. Cholecystokinin (CCK) is a neuropeptide which is widely distributed in the mammalian central nervous system. The CCKA receptor has a limited distribution with highest densities in the hypothalamic nuclei, areas of the hippocampus, the septum, dorsal motor vagal nucleus and interpeduncular nucleus of the brain stem. It also occurs in numerous gastro-intestinal tissues. CCKA receptors affect satiety, pancreatitis, gut motility and have growth-promoting effects on some tumors.

Background

Cholecystokinin (CCK) is a neuropeptide which is widely distributed in the mammalian central nervous system. Two CCK receptors have been identified to mediate the effects of CCK/gastrin family: CCKA (or CCK-1) receptor and CCKB (or CCK-2 or gastrin receptor). The CCKA receptor has a more limited distribution with highest densities in the hypothalamic nuclei, areas of the hippocampus, the septum, dorsal motor vagal nucleus and interpeduncular nucleus of the brain stem. It also occurs in numerous gastro-intestinal tissues. CCKA receptors affect satiety, pancreatitis, gut motility and have growth-promoting effects on some tumors.
General Info
Synonyms CCK1
Product Description Human CCKA Cholecystokinin Receptor-expressing GPCR (G protein-coupled receptor) division-arrested cells. Cholecystokinin (CCK) is a neuropeptide which is widely distributed in the mammalian central nervous system. The CCKA receptor has a limited distribution with highest densities in the hypothalamic nuclei, areas of the hippocampus, the septum, dorsal motor vagal nucleus and interpeduncular nucleus of the brain stem. It also occurs in numerous gastro-intestinal tissues. CCKA receptors affect satiety, pancreatitis, gut motility and have growth-promoting effects on some tumors.
Target Type GPCR
Product Type EZCells™ DA
Receptor Cholecystokinin
Sub-Type CCKA
Therapeutic Area metabolic & gastrointestinal
Related Services Membrane Preparation, GPCR Screening
Genbank Accession Number NM_000730
Validated Assay/Platform calcium
References Pisegna JR, de Weerth A, Huppi K, Wank SA. (1994) Molecular cloning, functional expression, and chromosomal localization of the human cholecystokinin type A receptor. Ann N Y Acad Sci. 713:338-42.
Ulrich CD, Ferber I, Holicky E, Hadac E, Buell G, Mil
EZCell Info
Host cell CHO-K1
Mycoplasma Status Negative (MycoAlert Kit)
Growth media Ham's F12, 10% FBS, 1% NEAA, 400 µg/mL G418
Storage and Packaging
Packaging Cryopreserved irradiated cells, 6 million cells per vial
Storage Recommendation liquid nitrogen
Quantity 6 million cells
Media
Specification Sheet  Download PDF Document