Human A1 Adenosine Receptor-expressing GPCR (G protein-coupled receptor) division-arrested cells. Adenosine is a neuromodulator that is widely distributed in the central and peripheral nervous systems. Modulation of adenosine receptors by selective agonists and antagonists has potential for the treatment of various cardiovascular inflammatory and neurological diseases. Learn More

Human Alpha2a Adrenergic Receptor-expressing GPCR (G protein-coupled receptor) division-arrested cells. Learn More

Human Alpha2c Adrenergic Receptor-expressing GPCR (G protein-coupled receptor) division-arrested cells. Learn More

Human BB2 Bombesin Receptor-expressing GPCR (G protein-coupled receptor) division-arrested cells. BB2 receptors are widely distributed in the CNS as well as in the gastrointestinal tract and reproductive organs. In CNS, Bombesin-like peptides induce satiety and play a role in thermoregulation and induce histamine-independent pruritus. These peptides also act via the BB2 receptor to regulate sleep disorders, depression and involved in the regulation of emotionally motivated learning, memory and food intake. In the gastrointestinal tract, GRPR receptors are involved in smooth muscle contractility, pancreatic secretion and the release of many other gastrointestinal peptides. Learn More

Human CB1 Cannabinoid Receptor-expressing GPCR (G protein-coupled receptor) division-arrested cells. Learn More

Rat CB1 Cannabinoid Receptor-expressing GPCR (G protein-coupled receptor) division-arrested cells. The CB1 cannabinoid receptor is expressed primarily in brain and is a target for cannabinoids. When activated, the CB1 receptor inhibits adenylate cyclase through Gi. Learn More

Human CB2 Cannabinoid Receptor-expressing GPCR (G protein-coupled receptor) division-arrested cells. Learn More

Rat CB2 Cannabinoid Receptor-expressing GPCR (G protein-coupled receptor) division-arrested cells.The CB2 cannabinoid receptor is expressed primarily in cells of the peripheral immune system and is a target for cannabinoids. When activated, the CB2 receptor inhibits adenylate cyclase by coupling through Gi. Learn More

Human Delta Opioid Receptor-expressing GPCR (G protein-coupled receptor) division-arrested cells. Learn More

Human ETA Endothelin Receptor-expressing GPCR (G protein-coupled receptor) division-arrested cells. Endothelins are a family of vasoactive peptides including ET-1, ET-2 and ET-3 in human. The EDNRA receptors (ETA) have a much greater affinity for ET-1 over ET-3 and are expressed abundantly in vascular smooth muscles and stromal tissues. The vasoconstrictor and proliferative effects of ET-1 are primarily mediated by the EDNRA receptor. This makes EDNRA a good target for drug development in a number of cardiovascular diseases, including congestive heart failure, hypertension, stroke, kidney failure, and a variety of non-cardiovascular conditions, such as asthma, chronic obstructive pulmonary disease, pain and cancer. Learn More

Human H1 Histamine Receptor-expressing GPCR (G protein-coupled receptor) division-arrested cells. Learn More

Human Kappa Opioid Receptor-expressing GPCR (G protein-coupled receptor) division-arrested cells. Learn More

Human Mrg-X1 Receptor-expressing GPCR (G protein-coupled receptor) division-arrested cells. Learn More

Human Mu Opioid Receptor-expressing GPCR (G protein-coupled receptor) division-arrested cells. Learn More

Human ORL1 Opioid Receptor-expressing GPCR (G protein-coupled receptor) division-arrested cells. Learn More

Human P2Y11 Purinergic Receptor-expressing GPCR (G protein-coupled receptor) division-arrested cells. Learn More

Human P2Y6 Purinergic Receptor-expressing GPCR (G protein-coupled receptor) division-arrested cells. Learn More

Human PAR2 Protease-Activated Receptor-expressing GPCR (G protein-coupled receptor) division-arrested cells. Learn More