Human 5HT2B Serotonin Receptor-expressing GPCR (G protein-coupled receptor) division-arrested cells. Learn More

Mouse 5HT2B Serotonin Receptor-expressing GPCR (G protein-coupled receptor) division-arrested cells. Learn More

Human A1 Adenosine Receptor-expressing GPCR (G protein-coupled receptor) division-arrested cells. Adenosine is a neuromodulator that is widely distributed in the central and peripheral nervous systems. Modulation of adenosine receptors by selective agonists and antagonists has potential for the treatment of various cardiovascular inflammatory and neurological diseases. Learn More

Human Alpha 1A Adrenergic Receptor-expressing GPCR (G protein-coupled receptor) division-arrested cells. Learn More

Human Alpha2a Adrenergic Receptor-expressing GPCR (G protein-coupled receptor) division-arrested cells. Learn More

Human Alpha2c Adrenergic Receptor-expressing GPCR (G protein-coupled receptor) division-arrested cells. Learn More

Human BB2 Bombesin Receptor-expressing GPCR (G protein-coupled receptor) division-arrested cells. BB2 receptors are widely distributed in the CNS as well as in the gastrointestinal tract and reproductive organs. In CNS, Bombesin-like peptides induce satiety and play a role in thermoregulation and induce histamine-independent pruritus. These peptides also act via the BB2 receptor to regulate sleep disorders, depression and involved in the regulation of emotionally motivated learning, memory and food intake. In the gastrointestinal tract, GRPR receptors are involved in smooth muscle contractility, pancreatic secretion and the release of many other gastrointestinal peptides. Learn More

Human CB1 Cannabinoid Receptor-expressing GPCR (G protein-coupled receptor) division-arrested cells. Learn More

Rat CB1 Cannabinoid Receptor-expressing GPCR (G protein-coupled receptor) division-arrested cells. The CB1 cannabinoid receptor is expressed primarily in brain and is a target for cannabinoids. When activated, the CB1 receptor inhibits adenylate cyclase through Gi. Learn More

Human CB2 Cannabinoid Receptor-expressing GPCR (G protein-coupled receptor) division-arrested cells. Learn More

Rat CB2 Cannabinoid Receptor-expressing GPCR (G protein-coupled receptor) division-arrested cells.The CB2 cannabinoid receptor is expressed primarily in cells of the peripheral immune system and is a target for cannabinoids. When activated, the CB2 receptor inhibits adenylate cyclase by coupling through Gi. Learn More

Human CCKA Cholecystokinin Receptor-expressing GPCR (G protein-coupled receptor) division-arrested cells. Cholecystokinin (CCK) is a neuropeptide which is widely distributed in the mammalian central nervous system. The CCKA receptor has a limited distribution with highest densities in the hypothalamic nuclei, areas of the hippocampus, the septum, dorsal motor vagal nucleus and interpeduncular nucleus of the brain stem. It also occurs in numerous gastro-intestinal tissues. CCKA receptors affect satiety, pancreatitis, gut motility and have growth-promoting effects on some tumors. Learn More

Human CCKB Cholecystokinin Receptor-expressing GPCR (G protein-coupled receptor) division-arrested cells. Cholecystokinin (CCK) is a neuropeptide which is widely distributed in the mammalian central nervous system. The CCKB receptor is the predominant subtype in the CNS where it is widely distributed, however, it also occurs in abundance in the gastro-intestinal tract. CCKB receptors have been found to be most abundant in the cerebral cortex, cerebellum, basal ganglia, and amygdale. Animal and human studies using CCKB receptor antagonists have suggested that anxiety, panic attacks, analgesia, and satiety may be modulated through the CCKB receptor. Learn More

Human Delta Opioid Receptor-expressing GPCR (G protein-coupled receptor) division-arrested cells. Learn More

Human ETA Endothelin Receptor-expressing GPCR (G protein-coupled receptor) division-arrested cells. Endothelins are a family of vasoactive peptides including ET-1, ET-2 and ET-3 in human. The EDNRA receptors (ETA) have a much greater affinity for ET-1 over ET-3 and are expressed abundantly in vascular smooth muscles and stromal tissues. The vasoconstrictor and proliferative effects of ET-1 are primarily mediated by the EDNRA receptor. This makes EDNRA a good target for drug development in a number of cardiovascular diseases, including congestive heart failure, hypertension, stroke, kidney failure, and a variety of non-cardiovascular conditions, such as asthma, chronic obstructive pulmonary disease, pain and cancer. Learn More

Human ETB Endothelin Receptor-expressing GPCR (G protein-coupled receptor) division-arrested cells. Endothelins are a family of vasoactive peptides that includes ET-1, ET-2 and ET-3. The EDNRA receptors have a much greater affinity for ET-1 over ET-3 and are expressed abundantly in vascular smooth muscles and stromal tissues. The EDNRB receptors bind ET-1, ET-2 and ET-3 with nearly equal affinity and are expressed abundantly in endothelial cells and epithelial tissues. Although the vasoconstrictor and proliferative effects of ET-1 are primarily mediated by EDNRA receptors, EDNRB receptors can also mediate the vasoconstrictor response through ET-1-induced nitric oxide release from endothelial cells. Learn More

Human FPRL1 Receptor-expressing GPCR (G protein-coupled receptor) division-arrested cells. Learn More

Human GIPR Gastric Inhibitory Polypeptide Receptor-expressing GPCR (G protein-coupled receptor) division-arrested cells. Gastric inhibitory polypeptide (GIP) is a 42-amino acid polypeptide synthesized by K-cells of the duodenum and small intestine. GIP’s principle physiological action is to stimulate insulin secretion from pancreatic β-cells in a glucose-dependent manner. Additional effects of GIP have been described, including effects on lipid metabolism, stimulation of glucagons and somatostatin release. GIP exerts its effects by binding to its specific receptor, the GIP receptor which belongs to the VIP/glucagon/secretin family of G protein-coupled receptors and is positively coupled to adenylyl cyclase but not to phospholipase C. Learn More

Human GPR103 Receptor-expressing GPCR (G protein-coupled receptor) division-arrested cells. Learn More