Human 5HT2B Serotonin Receptor-expressing GPCR (G protein-coupled receptor) division-arrested cells. Learn More

Mouse 5HT2B Serotonin Receptor-expressing GPCR (G protein-coupled receptor) division-arrested cells. Learn More

Human A1 Adenosine Receptor-expressing GPCR (G protein-coupled receptor) division-arrested cells. Adenosine is a neuromodulator that is widely distributed in the central and peripheral nervous systems. Modulation of adenosine receptors by selective agonists and antagonists has potential for the treatment of various cardiovascular inflammatory and neurological diseases. Learn More

Human ETA Endothelin Receptor-expressing GPCR (G protein-coupled receptor) division-arrested cells. Endothelins are a family of vasoactive peptides including ET-1, ET-2 and ET-3 in human. The EDNRA receptors (ETA) have a much greater affinity for ET-1 over ET-3 and are expressed abundantly in vascular smooth muscles and stromal tissues. The vasoconstrictor and proliferative effects of ET-1 are primarily mediated by the EDNRA receptor. This makes EDNRA a good target for drug development in a number of cardiovascular diseases, including congestive heart failure, hypertension, stroke, kidney failure, and a variety of non-cardiovascular conditions, such as asthma, chronic obstructive pulmonary disease, pain and cancer. Learn More

Human ETB Endothelin Receptor-expressing GPCR (G protein-coupled receptor) division-arrested cells. Endothelins are a family of vasoactive peptides that includes ET-1, ET-2 and ET-3. The EDNRA receptors have a much greater affinity for ET-1 over ET-3 and are expressed abundantly in vascular smooth muscles and stromal tissues. The EDNRB receptors bind ET-1, ET-2 and ET-3 with nearly equal affinity and are expressed abundantly in endothelial cells and epithelial tissues. Although the vasoconstrictor and proliferative effects of ET-1 are primarily mediated by EDNRA receptors, EDNRB receptors can also mediate the vasoconstrictor response through ET-1-induced nitric oxide release from endothelial cells. Learn More

Human M1 Muscarinic Receptor-expressing GPCR (G protein-coupled receptor) division-arrested cells. Learn More

Human M2 Muscarinic Receptor-expressing GPCR (G protein-coupled receptor) division-arrested cells. Learn More

Human M3 Muscarinic Receptor-expressing GPCR (G protein-coupled receptor) division-arrested cells. Learn More