Human BB2 Bombesin Receptor-expressing GPCR (G protein-coupled receptor) division-arrested cells. BB2 receptors are widely distributed in the CNS as well as in the gastrointestinal tract and reproductive organs. In CNS, Bombesin-like peptides induce satiety and play a role in thermoregulation and induce histamine-independent pruritus. These peptides also act via the BB2 receptor to regulate sleep disorders, depression and involved in the regulation of emotionally motivated learning, memory and food intake. In the gastrointestinal tract, GRPR receptors are involved in smooth muscle contractility, pancreatic secretion and the release of many other gastrointestinal peptides. Learn More