Human Alpha 1A Adrenergic Receptor-expressing GPCR (G protein-coupled receptor) division-arrested cells. Learn More

Human Alpha2a Adrenergic Receptor-expressing GPCR (G protein-coupled receptor) division-arrested cells. Learn More

Human ETA Endothelin Receptor-expressing GPCR (G protein-coupled receptor) division-arrested cells. Endothelins are a family of vasoactive peptides including ET-1, ET-2 and ET-3 in human. The EDNRA receptors (ETA) have a much greater affinity for ET-1 over ET-3 and are expressed abundantly in vascular smooth muscles and stromal tissues. The vasoconstrictor and proliferative effects of ET-1 are primarily mediated by the EDNRA receptor. This makes EDNRA a good target for drug development in a number of cardiovascular diseases, including congestive heart failure, hypertension, stroke, kidney failure, and a variety of non-cardiovascular conditions, such as asthma, chronic obstructive pulmonary disease, pain and cancer. Learn More

Human ETB Endothelin Receptor-expressing GPCR (G protein-coupled receptor) division-arrested cells. Endothelins are a family of vasoactive peptides that includes ET-1, ET-2 and ET-3. The EDNRA receptors have a much greater affinity for ET-1 over ET-3 and are expressed abundantly in vascular smooth muscles and stromal tissues. The EDNRB receptors bind ET-1, ET-2 and ET-3 with nearly equal affinity and are expressed abundantly in endothelial cells and epithelial tissues. Although the vasoconstrictor and proliferative effects of ET-1 are primarily mediated by EDNRA receptors, EDNRB receptors can also mediate the vasoconstrictor response through ET-1-induced nitric oxide release from endothelial cells. Learn More

Human P2Y1 Purinergic Receptor-expressing GPCR (G protein-coupled receptor) division-arrested cells. P2Y1 couples preferentially to Gq/11 and is expressed in a variety of tissues including platelets, endothelia, smooth muscle, CNS, osteoblasts and B-islet cells. Learn More

Human P2Y6 Purinergic Receptor-expressing GPCR (G protein-coupled receptor) division-arrested cells. Learn More

Human V2 Vasopressin Receptor-expressing GPCR (G protein-coupled receptor) division-arrested cells. Learn More