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Background
Serotonin (5-hydroxytryptamine, 5-HT) exerts its many physiological effects through 13 distinct receptor subtypes in humans. These subtypes fall into seven structurally-defined classes (5HT1 to 5HT7). 5-HT6 receptor is expressed in several human brain regions, most prominently in the caudate nucleus. It is positively coupled to adenylcyclase and has pharmacological properties with high affinity for several therapeutically important antidepressant and antipsychotic drugs, in particular the atypical antipsychotic clozapine and related compounds.
| General Info | |
| Synonyms | HTR6 |
|---|---|
| Product Description | Human Serotonin 5-HT6 Receptor-expressing GPCR (G protein-coupled receptor) stable, replicating cell line. |
| Target Type | GPCR |
| Product Type | Replicating Cell Line |
| Receptor | Serotonin |
| Sub-Type | 5-HT6 |
| Therapeutic Area | metabolic & gastrointestinal, neurodegeneration & stroke, psychiatric disorder |
| Related Services | Membrane Preparation, Large-scale Cryopreservation, GPCR Screening |
| Genbank Accession Number | NM_000871 |
| Validated Assay/Platform | binding |
| References | Kohen, R., et al. (1996) Cloning, Characterization, and Chromosomal Localization of a Human 5-HT6 Serotonin Receptor. J Neurochem. 1996 Jan;66(1):47-56. Barnes, N.M. (1999) A review of central 5-HT receptors and their function. Neuropharmacology |
| Host cell | CHO-K1 |
| Mycoplasma Status | Negative (MycoAlert Kit) |
| Growth media | Ham's F12, 10% dFBS, 1% NEAA, 0.5 mg/mL G418 |
| Storage & Packaging | |
| Packaging | Cryopreserved cells, 6 million cells per vial |
| Storage Recommendation | liquid nitrogen |
| Stability | 12 passages of continuous culture (6 weeks) at 2 passages/week |
| Quantity | 6 million cells |
| Product Documentation | |
| Specification Sheet |  Download PDF Document |