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Background
The human P2Y family of metabotropic receptors include eight accepted members, including P2Y1,2,4,6,11,12,13,14. P2Y2,4,11 are activated mainly by nucleoside triphosphates whereas P2Y1,6,12,13 are activated by nucleoside diphosphates. P2Y1 couples preferentially to Gq/11 and is expressed in a variety of tissues including platelets, endothelia, smooth muscle, CNS, osteoblasts and B-islet cells.
| General Info | |
| Synonyms | P2RY1 |
|---|---|
| Product Description | Human P2Y1 Purinergic Receptor-expressing GPCR (G protein-coupled receptor) division-arrested cells. P2Y1 couples preferentially to Gq/11 and is expressed in a variety of tissues including platelets, endothelia, smooth muscle, CNS, osteoblasts and B-islet cells. |
| Target Type | GPCR |
| Product Type | EZCells™ DA |
| Receptor | Purinergic |
| Sub-Type | P2Y1 |
| Therapeutic Area | neurodegeneration & stroke, vascular |
| Related Services | Membrane Preparation, GPCR Screening |
| Genbank Accession Number | NM_002563 |
| Validated Assay/Platform | calcium |
| References | acobson, K.A., et al., (2004) Molecular recognition at purine and pyrimidine nucleotide (P2) receptors. Curr. Top. Med. Chem. 4: 805-819. Burnstock, G., et al., (2004) Cellular distribution and functions of P2 receptor subtypes in different syste |
| EZCell Info | |
| Host cell | 1321N1 astrocytoma |
| Mycoplasma Status | Negative (MycoAlert Kit) |
| Growth media | DMEM, 10% FBS, 400 µg/mL G418 |
| Storage and Packaging | |
| Packaging | Cryopreserved irradiated cells, 6 million cells per vial |
| Storage Recommendation | liquid nitrogen |
| Quantity | 6 million cells |
| Media | |
| Specification Sheet |  Download PDF Document |
