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Background
The human KCNQ3 and KCNQ5 genes encode the pore-forming subunits of Kv7.3 and Kv7.5, respectively. These subunits form heteromeric voltage-gated potassium channels that underlie M-current that regulates repetitive activity in neurons. Mutations in KCNQ3 that reduce M-current are responsible for some forms of benign familial neonatal seizure. Kv7.3/Kv7.5 channels expressed in neurons are therapeutic targets in seizure and cognitive impairment.
| General Info | |
| Synonyms | KCNQ3/KCNQ5 |
|---|---|
| Product Description | Human Kv7.3/Kv7.5 potassium ion channel-expressing, stable replicating cell line. |
| Target Type | Ion Channel |
| Product Type | Replicating Cell Line |
| Family | Potassium, Voltage-Gated |
| Sub-Type | Kv7.3/Kv7.5 |
| Class | Voltage-gated potassium channel |
| Therapeutic Area | psychiatric disorder, seizure-convulsion |
| Related Services | Large-scale Cryopreservation |
| Gene Name | KCNQ3/KCNQ5 |
| Validated Assay/Platform | FLIPR®, PatchXpress®, QPatch HT |
| References | Gutman GA, et al. 2005. Pharmacol Rev. 57:473-508. International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. |
| Host cell | HEK293 |
| Mycoplasma Status | Negative (MycoAlert Kit) |
| Storage & Packaging | |
| Packaging | Cryopreserved cells, 1-2x106 cells |
| Storage Recommendation | liquid nitrogen |
| Quantity | 1-2 million cells |
| Product Documentation | |
| Specification Sheet |  Download PDF Document |
