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Background
The human KCNJ2 gene encodes the pore-forming subunit of Kir2.1, an inwardly rectifying potassium channel. Mutations in KCNJ2 have been linked to inherited cardiac diseases including Andersens syndrome (a form of long QT with neurologic involvement), Short QT syndrome, and familial atrial fibrillation. Kir2.1 channels expressed in heart are anti-targets in cardiac risk assessment.
| General Info | |
| Product Description | Human Kir2.1 potassium ion channel-expressing, transiently transfected cells. |
|---|---|
| Target Type | Ion Channel |
| Product Type | EZCells™ TT |
| Family | Potassium, Inward Rectifier |
| Sub-Type | Kir2.1 (IK1) |
| Class | Inward rectifier potassium channel |
| Therapeutic Area | cardiac |
| Related Services | Cardiac Ion Channel Panel™, Ion Channel Trafficking Assays |
| Gene Name | KCNJ2 |
| Genbank Accession Number | NM_000891.2 |
| Validated Assay/Platform | manual patch clamp |
| References | Kubo Y, et al. 2005. Pharmacol Rev. 57:509-526. International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels. |
| EZCell Info | |
| Host cell | HEK293 |
| Mycoplasma Status | Negative (MycoAlert Kit) |
| Growth media | DMEM/F12/10% FBS |
| Functional expression | Ba2+ -sensitive current amplitude at -110 mV (mean ± SEM) = 1.2 ± 0.13 nA, n = 7 manual patch clamp recordings |
| Storage and Packaging | |
| Packaging | Cryopreserved cells, 6x106 cells/vial |
| Storage Recommendation | liquid nitrogen |
| Quantity | 6 million cells |
