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Background
The human KCNN2 gene encodes the pore-forming subunit of KCa2.2, the calcium-activated, voltage-gated SK2 potassium channel. KCa2 channels are responsible for afterhyperpolarization that regulates neuronal repetitive excitation. KCa2.2 channels expressed in CNS neurons are therapeutic targets in neurologic disorders (e.g., cognitive impairment and seizure).
| General Info | |
| Synonyms | SK2 |
|---|---|
| Product Description | Human KCa2.2 potassium ion channel-expressing, stable replicating cell line. |
| Target Type | Ion Channel |
| Product Type | Replicating Cell Line |
| Family | Potassium, Calcium-Activated |
| Sub-Type | KCa2.2 |
| Class | calcium-activated potassium channel |
| Therapeutic Area | seizure-convulsion |
| Related Services | Large-scale Cryopreservation |
| Gene Name | KCNN2 |
| Validated Assay/Platform | FLIPR®, manual patch clamp |
| References | Wei AD, et al. 2005. Pharmacol Rev. 57:463-472. International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium activated-potassium channels. Fanger CM, et al. 2001. J Biol Chem. 276:12249-12256. Calcium-activated potass |
| Host cell | CHO-K1 |
| Mycoplasma Status | Negative (MycoAlert Kit) |
| Storage & Packaging | |
| Packaging | Cryopreserved cells, 1-2x106 cells |
| Storage Recommendation | liquid nitrogen |
| Quantity | 1-2 million cells |
| Product Documentation | |
| Specification Sheet |  Download PDF Document |
