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Human HCN4 Hyperpolarization-gated Channel Cell Line

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  • Voltage-dependent gating and pharmacological characteristics of hHCN4 recorded by PatchXpress®. Hyperpolarization-dependent activation. Currents were elicited by test pulses from 30 to 140 mV in 10 mV decrements from a holding potential of ‑20 mV.
  • Voltage-dependent gating and pharmacological characteristics of hHCN4 recorded by PatchXpress® - current-voltage relationship.
  • Voltage-dependent gating and pharmacological characteristics of hHCN4 recorded by PatchXpress®. Effect of 1 and 10 µM zatebradine on hHCN4 currents evoked by test potentials to -120 mV.
  • Voltage-dependent gating and pharmacological characteristics of hHCN4 recorded by PatchXpress®. Zatebradine concentration-response relationship. The IC50 value was 1.4 µM.

Human HCN4 Hyperpolarization-gated Channel Cell Line

  • Cat.#:
  • CT6006

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Quick Overview

Human HCN4 hyperpolarization-gated ion channel-expressing, stable replicating cell line (HEK).

Background

The human HCN4 gene encodes the pore-forming subunit of a hyperpolarization-activated, cyclic nucleotide-modulated cation channel. HCN4 channels are the predominant HCN isoform in the sinoatrial node and contribute to pacemaker current that controls rhythmic activity in the heart and brain. The HCN4 therapeutic potential includes treatment of cardiac arrhythmia and ischemic heart disease.
General Info
Synonyms hyperpolarization-activated, cyclic nucleotide-gated channel
Product Description Human HCN4 hyperpolarization-gated ion channel-expressing, stable replicating cell line (HEK).
Target Type Ion Channel
Product Type Replicating Cell Line
Family Hyperpolarization-gated
Sub-Type HCN4
Class Hyperpolarization-gated channel
Therapeutic Area cardiac
Related Services Cardiac Ion Channel Panel™, Large-scale Cryopreservation
Gene Name HCN4
Validated Assay/Platform manual patch clamp, PatchXpress®
References Hofmann F, et al. 2005. Pharmacol Rev. 57:455-462. International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels.
Host cell HEK293
Mycoplasma Status Negative (MycoAlert Kit)
Storage & Packaging
Packaging Cryopreserved cells, 1-2x106 cells
Storage Recommendation liquid nitrogen
Quantity 1-2 million cells
Product Documentation
Specification Sheet  Download PDF Document