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Background
The human HCN4 gene encodes the pore-forming subunit of a hyperpolarization-activated, cyclic nucleotide-modulated cation channel. HCN4 channels are the predominant HCN isoform in the sinoatrial node and contribute to pacemaker current that controls rhythmic activity in the heart and brain. The HCN4 therapeutic potential includes treatment of cardiac arrhythmia and ischemic heart disease.
| General Info | |
| Synonyms | hyperpolarization-activated, cyclic nucleotide-gated channel |
|---|---|
| Product Description | Human HCN4 hyperpolarization-gated ion channel-expressing, stable replicating cell line (CHO). |
| Target Type | Ion Channel |
| Product Type | Replicating Cell Line |
| Family | Hyperpolarization-gated |
| Sub-Type | HCN4 |
| Class | Hyperpolarization-gated channel |
| Therapeutic Area | cardiac |
| Related Services | Cardiac Ion Channel Panel™, Large-scale Cryopreservation |
| Gene Name | HCN4 |
| Validated Assay/Platform | IonWorks Quattro™, QPatch HT |
| References | Hofmann F, et al. 2005. Pharmacol Rev. 57:455-462. International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels. Stieber J, Wieland K, Stöckl G, Ludwig A, Hofmann F. 2006. Bradycar |
| Host cell | CHO |
| Mycoplasma Status | Negative (MycoAlert Kit) |
| Storage & Packaging | |
| Packaging | Cryopreserved cells, 1-2x106 cells |
| Storage Recommendation | liquid nitrogen |
| Quantity | 1-2 million cells |
| Product Documentation | |
| Specification Sheet |  Download PDF Document |
