Cholecystokinin (CCK) is a neuropeptide which is widely distributed in the mammalian central nervous system. Two CCK receptors have been identified to mediate the effects of CCK/gastrin family: CCKA (or CCK-1) receptor and CCKB (or CCK-2 or gastrin receptor). The CCKA receptor has a more limited distribution with highest densities in the hypothalamic nuclei, areas of the hippocampus, the septum, dorsal motor vagal nucleus and interpeduncular nucleus of the brain stem. It also occurs in numerous gastro-intestinal tissues. CCKA receptors affect satiety, pancreatitis, gut motility and have growth-promoting effects on some tumors.
|Product Description||Human Cholecystokinin CCKA Receptor-expressing GPCR (G protein-coupled receptor) stable, replicating cell line.|
|Product Type||Replicating Cell Line|
|Therapeutic Area||metabolic & gastrointestinal|
|Related Services||Membrane Preparation, Large-scale Cryopreservation, GPCR Screening|
|Genbank Accession Number||NM_000730|
|References||Pisegna JR, de Weerth A, Huppi K, Wank SA. (1994) Molecular cloning, functional expression, and chromosomal localization of the human cholecystokinin type A receptor. Ann N Y Acad Sci. 713:338-42.
Ulrich CD, Ferber I, Holicky E, Hadac E, Buell G, Mil
|Mycoplasma Status||Negative (MycoAlert Kit)|
|Growth media||Ham's F12, 10% FBS, 1% NEAA, 400 µg/mL G418|
|Storage & Packaging|
|Packaging||Cryopreserved cells, 6 million cells per vial|
|Storage Recommendation||liquid nitrogen|
|Stability||12 passages (6 weeks of continuous culture)|
|Quantity||6 million cells|
|Specification Sheet||Download PDF Document|