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Background
The human CACNA1C gene encodes the pore-forming subunits of Cav1.2. CACNB2 and CACNA2D1 encode auxiliary subunits that modulate gating and pharmacological properties. Cav1.2 channels expressed in heart, smooth muscle, neurons, and endocrine tissue are therapeutic targets in cardiac arrhythmia and hypertension.
| General Info | |
| Synonyms | L-type calcium channel |
|---|---|
| Product Description | Human Cav1.2/β2/α2δ1 calcium ion channel-expressing, stable replicating cell line. |
| Target Type | Ion Channel |
| Product Type | Replicating Cell Line |
| Family | Calcium, Voltage-Gated |
| Sub-Type | Cav1.2/β2/α2δ1 |
| Class | Voltage-gated calcium channel |
| Therapeutic Area | cancer, cardiac, vascular |
| Related Services | Cardiac Ion Channel Panel™, Large-scale Cryopreservation |
| Gene Name | CACNA1C/CACNB2/CACNA2D1 |
| Validated Assay/Platform | IonWorks Quattro™, manual patch clamp, PatchXpress®, QPatch HT |
| References | Catterall WA, et al. 2005. Pharmacol Rev. 57:411-425. International Union of Pharmacology. XLVIII. Nomenclature and molecular relationships of voltage-gated calcium channels. |
| Host cell | CHO |
| Mycoplasma Status | Negative (MycoAlert Kit) |
| Storage & Packaging | |
| Packaging | Cryopreserved cells, 1-2x106 cells |
| Storage Recommendation | liquid nitrogen |
| Quantity | 1-2 million cells |
| Product Documentation | |
| Specification Sheet |  Download PDF Document |
