Three alpha2-adrenoceptors have been cloned, and are designated alpha2a, alpha2b and alpha2c. All three receptors are activated by norepinephrine and all three are coupled via Gi to adenylate cyclase. The alpha2c adrenergic receptor is widely distributed in the CNS and in lung and mediates vasoconstriction and modulation of neurotransmission.
|Product Description||Human Alpha2c Adrenergic Receptor-expressing GPCR (G protein-coupled receptor) division-arrested cells.|
|Product Type||EZCells™ DA|
|Therapeutic Area||pain & inflammation, psychiatric disorder|
|Related Services||Membrane Preparation, GPCR Screening|
|Genbank Accession Number||NM_000683|
|Validated Assay/Platform||binding, cAMP|
|References||Hieble, J.P., et al, (1995) Alpha and beta-adrenoceptors: From the gene to the clinic. Part I. J. Med. Chem. 38: 3415-3444.
Regan, J.W. et al (1988) Cloning and expression of a human kidney cDNA for an alpha2-adrenergic receptor subtype. Pro
|Mycoplasma Status||Negative (MycoAlert Kit)|
|Growth media||Ham's F12, 10% dialyzed FBS, 1% NEAA, 400 µg/mL G418|
|Storage and Packaging|
|Packaging||Cryopreserved irradiated cells, 6 million cells per vial|
|Storage Recommendation||liquid nitrogen|
|Quantity||6 million cells|
|Specification Sheet||Download PDF Document|