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Background
Alpha-1 adrenergic receptors are widely distributed and mediate a variety of functions including smooth muscle contraction, cardiac stimulation, cellular proliferation, apoptosis and activation of hepatic gluconeogenesis and clycogenolysis. Three distinct alpha-1 adrenergic receptors have been identified and are known as alpha-1a, alpha-1b, and alpha-1c receptors.
| General Info | |
| Synonyms | ADRA1A |
|---|---|
| Product Description | Human Alpha-1a Adrenergic Receptor-expressing GPCR (G protein-coupled receptor) stable, replicating cell line. |
| Target Type | GPCR |
| Product Type | Replicating Cell Line |
| Receptor | Adrenergic |
| Sub-Type | Alpha1a |
| Therapeutic Area | cardiac, genitourinary, vascular |
| Related Services | Membrane Preparation, Large-scale Cryopreservation, GPCR Screening |
| Genbank Accession Number | Amino acid sequence corresponds exactly to AY389505; no expressed tags. |
| Validated Assay/Platform | calcium |
| References | Schwinn, D.A. and Price, R.R. (1999) Molecular pharmacology of human alpha 1-adrenergic receptors: Unique features of the alpha-1a subtype. Eur. Urol. 36: 7-10 Schwinn, D.A. et al . (1995) Cloning and pharmacological characterization of human |
| Host cell | CHO-K1 |
| Mycoplasma Status | Negative (MycoAlert Kit) |
| Growth media | Ham's F12, 10% dialyzed FBS, 0.4 mg/mL G418 |
| Storage & Packaging | |
| Packaging | Cryopreserved cells, 6 million cells per vial |
| Storage Recommendation | liquid nitrogen |
| Stability | 6 passages (4 weeks of continuous culture) |
| Quantity | 6 million cells |
| Product Documentation | |
| Specification Sheet |  Download PDF Document |
