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Background
Serotonin (5-hydroxytryptamine, 5-HT) exerts its many physiological effects through 13 distinct receptor subtypes in humans. These subtypes fall into seven structurally-defined classes (5HT1 to 5HT7). 5HT2c receptors are expressed in brain and choroid plexus. This receptor has been used as a target for developing drugs to treat migraine and obesity.
| General Info | |
| Product Description | Frozen membranes from CHO-K1 cells expressing recombinant human 5HT2c Serotonin receptors. |
|---|---|
| Target Type | GPCR |
| Product Type | membrane |
| Receptor | Serotonin |
| Sub-Type | 5HT2c |
| Therapeutic Area | metabolic & gastrointestinal, neurodegeneration & stroke, psychiatric disorder |
| Related Services | Membrane Preparation, GPCR Screening |
| Genbank Accession Number | NM_000868 |
| References | Choi, D.-S. et al. (1994) The human serotonin 5-HT2B receptor: pharmacological link between 5-HT2 and 5-HT1D receptors. FEBS Lett. 352: 393-399. Barnes, N.M. (1999) A review of central 5-HT receptors and their function. Neuropharmacology 38: 1 |
| Membrane Info | |
| Host cell | CHO-K1 |
| Bmax | 11 pmol/mg |
| KD | 14 nM |
| Recommended Assay Conditions | Refer to product specification sheet for details |
| Storage and Packaging | |
| Packaging | Vials contain 400 µl of membrane suspension in storage buffer (50mM Tris-HCI pH 7.4, 10% sucrose) at a protein concentration of 2 mg/mL |
| Storage Recommendation | Storage at -80oC is recommended. Repeated freeze-thawing of this product is not recommended. |
| Quantity | 400 µL/vial |
| Media | |
| Specification Sheet |  Download PDF Document |
