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Background
Serotonin (5-hydroxytryptamine, 5-HT) exerts its many physiological effects through 13 distinct receptor subtypes in humans. These subtypes fall into seven structurally-defined classes (5-HT1 to 5-HT7). Among them, 5-HT1a receptors are expressed mainly in the CNS where they induce neuronal inhibition and control behavior, such as sleep, food intake, thermoregulation, aggression, and anxiety. This receptor has been used as a target for developing drugs to treat anxiety and depression.
| General Info | |
| Synonyms | HTR1A |
|---|---|
| Product Description | Human 5HT1A Serotonin Receptor-expressing GPCR (G protein-coupled receptor) stable, replicating cell line. |
| Target Type | GPCR |
| Product Type | Replicating Cell Line |
| Receptor | Serotonin |
| Sub-Type | 5HT1A |
| Therapeutic Area | neurodegeneration & stroke, psychiatric disorder |
| Related Services | Membrane Preparation, Large-scale Cryopreservation, GPCR Screening |
| Genbank Accession Number | NM_000524 |
| Validated Assay/Platform | binding, cAMP |
| References | Raymond, J.R., et al. (1999) The recombinant 5-HT1A receptor: G protein coupling and signaling pathways. Br J Pharmacol. 127(8):1751-64. Barnes, N.M. (1999) A review of central 5-HT receptors and their function. Neuropharmacology 38: 1083-1152. |
| Host cell | CHO-K1 |
| Mycoplasma Status | Negative (MycoAlert Kit) |
| Growth media | Ham's F12, 10% dFBS, 1% NEAA, 400 µg/mL G418 |
| Storage & Packaging | |
| Packaging | Cryopreserved cells, 6 million cells per vial |
| Storage Recommendation | liquid nitrogen |
| Stability | 12 passages of continuous culture (6 weeks at 2 passages/week) |
| Quantity | 6 million cells |
| Product Documentation | |
| Specification Sheet |  Download PDF Document |
